Romania acquired twelve Bf.110C-3 during later 1942 which were assigned to Escadrila 51 Vânâtoare de Noapte (Night Fighter Squadron 51), which was later renamed as Escadrila 1. This unit was, for the time, experimental for the Aeronautica Regala Romana (Royal Romanian Air Force - ARR for short) and was created to defend the country against the fore coming Allied night raids. In spring 1944, however, the Bf.100C-3 was gradually replaced by the Bf.110F-4 which was more powerful.
The Escadrila 51 acted integrated within the Luftwaffe ranks and saw plenty of action during the American raids. One of their first actions took place on 1st August 1943 when American B-24 bombers attacked the country and the ARR scrambled many fighters, including the Bf.110Cs of Escadrila 51, to fight them. During this action the Squadron Commander, Cpt. Av. Ghica' Marin claimed one American bomber, however his aircraft was shot down by the B-24's gunners and he couldn't bail out from the burning Bf.110C, where he perished. His rear-gunner managed to bail out.
Shortly later, on 10th August 1943 Slt. Av. Mihail Brâncoveanu, an aristocrat from an old family of Romanian rulers, who was married to the daughter of the Spanish ambassador to Bucharest, with his radio operator Maistru Paun Busuioc and rear-gunner Maistru Dumitru Gologan scrambled to intercept another formation of American bombers detected over the town of Nis, Yugoslavia, on route to Ploiesti, Romania. However, due to the lack of experience with radio-assisted direction finding, they got lost and eventually ran of out fuel near Sinaia, north-west of Bucharest, both radio-operator and rear-gunner bailed out safely but Brâncoveanu died.
On the 4th April 1944, another raid took place. By this date the Escadrila 51 had already became the Escadrila 1 Vânâtoare de Noapte and was integrated into Luftwaffe's command as 12./Nachtjagdgeschwader 6. That day two Bf.110 belonging to Escadrila 1 took off to intercept American bombers. The Bf.110 bore German markings and too-off from Zilistea airfield, following orders from the German command. One of those two machines, crewed by Adj. Av. Ioan Popescu as pilot and Serg. Georghe Dumitru as radio operator and rear-gunner took fire in the left engine and made a forced landing west of Caracal, south-west of Romania. The other Bf.110C-3 with Slt. Av. Gheorghe Stânciucu and rear-gunner Serg. Gheorghe Drâgan was shot down six kilometres from the village of Rediu, killing both crew members and completely destroying the aircraft.
The following day, on 5th April another interception attempt took place, also in Zilistea, when one Bf.110C-3 took-off and joined the aerial battle that was taking place west of Ploiesti, but it was shot down too, killing its pilot.
On 10th June 1944 a formation of 100 Lockheed P-38 Lightining fighters from the USAAF made a low-level attack, so, in order to protect the fighters on the ground, the German command ordered the fighters to be dispersed on various airfields.
During the summer 1944 the Bf.110F had already replaced the Bf.110C and some other interception attempts took place with similar results, as the ARR couldn't cope with the overwhelming aerial superiority of the USAAF.
When Romania signed the armistice on 23rd August 1944 and switched sides, most of the Bf.110 that were still intact were confiscated by the Soviets. However, at least one Bf.110F was kept and was used for liaison purposes, during April 1945 at Trencin, Czechoslovakia.
There's only one Bf.110F documented to have flown with Romanian markings, this machine, coded as 2Z+AW was flown by Lt. Av. Ion Simion with Constantin Octavian as his rear-gunner and was part of Escadrila 51. It was based at Otopeni airfield, close to Bucharest.
Sources:
1st Mushroom Model Magazine - White Series 9111 - Romanian Fighter colour 1941-1945
2nd https://www.tapatalk.com/groups/hyperscale/info-on-romanian-bf-110-fs-t201430.html
3rd https://en.wikipedia.org/wiki/Messerschmitt_Bf_110#Operators













